FUNDING

Dr Trempe is a member of the Centre de Recherche en Biologie Structurale, a center funded by the FRQS: 
https://www.crbsmcgill.ca

CANADIAN INSTITUTES OF HEALTH RESEARCH (CIHR)

Structural and mechanistic studies of PINK1, a mitochondrial ubiquitin kinase implicated in Parkinson's disease. 

2017-2022

Principal Investigator: Jean-François Trempe

Collaborators: Gergely Lukacs, Edward Fon

Canada Research Chair in Structural Pharmacology (Tier 2)

2014-2024

NATURAL SCIENCES AND ENGINEERING RESEARCH COUNCIL (NSERC)

Structural and functional studies of ubiquitin kinases.

2015-2022

Principal Investigator: Jean-François Trempe

MICHAEL J FOX FOUNDATION

 

Structure of human PINK1-TOM complex by single-particle cryo-EM

2020-2022

Principal Investigator: Jean-François Trempe 

Co-PIs: Edward Fon, Joaquin Ortega

Characterization of new Parkin activation mutants.

2017-2020

Principal Investigator: Jean-François Trempe 

Co-PIs: Edward Fon, Thomas Durcan, Miratul Muqit, Wolfdieter Springer

Structure-based design of small-molecule activators of Parkin.

2016-2020

Principal Investigator: Jean-François Trempe

Collaborators: David Drewry, William Zuercher, Aled Edwards (SGC)

Crystal Structure of PINK1.

2016-2017

Principal Investigator: Jean-François Trempe

Collaborators: Gergely Lukacs

HEALTHY BRAIN FOR HEALTHY LIVES

Measuring protein turnover in organoid and animal models of Parkinson’s disease.

2018-2020

Principal Investigator: Jean-François Trempe

Collaborators: Thomas Durcan, Edward Fon

CANADIAN FUND FOR INNOVATION (CFI)

Leaders Opportunity Fund (LOF) linked to Canada Research Chair. Structural Pharmacology of Parkinson's disease.

2014-2019

Principal Investigator: Jean-François Trempe

PARKINSON CANADA

Small molecule stabilizers as PINK1 agonists: a proof-of-concept study.

2017-2018

Principal Investigator: Jean-François Trempe

New Investigator Award. Crystal structure of PINK1.

2014-2016

Principal Investigator: Jean-François Trempe