FUNDING
Dr Trempe is a member of the Centre de Recherche en Biologie Structurale, a center funded by the FRQS:
https://www.crbsmcgill.ca
CANADIAN INSTITUTES OF HEALTH RESEARCH (CIHR)
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Structural studies and development of chemical probes for PINK1, a mitochondrial ubiquitin kinase implicated in Parkinson's disease.
2023-2028
Principal Investigator: Jean-François Trempe
Collaborators: Nicolas Moitessier, Edward Fon
Structural and mechanistic studies of PINK1, a mitochondrial ubiquitin kinase implicated in Parkinson's disease.
2017-2022
Principal Investigator: Jean-François Trempe
Collaborators: Gergely Lukacs, Edward Fon
Canada Research Chair in Structural Pharmacology (Tier 2)
2014-2024
NATURAL SCIENCES AND ENGINEERING RESEARCH COUNCIL (NSERC)
Structure-guided investigation of the mechanisms linking protein import, substrate processing, and respiration in mitochondria.
2022-2027
Principal Investigator: Jean-François Trempe
Structural and functional studies of ubiquitin kinases.
2015-2022
Principal Investigator: Jean-François Trempe
MICHAEL J FOX FOUNDATION
Mechanistic insights into PINK1 genetic variants
Principal Investigator: Jean-François Trempe
Structure of human PINK1-TOM complex by single-particle cryo-EM
2020-2025
Principal Investigator: Jean-François Trempe
Co-PIs: Edward Fon, Joaquin Ortega, Mohamed Eldeeb
Characterization of new Parkin activation mutants.
2017-2020
Principal Investigator: Jean-François Trempe
Co-PIs: Edward Fon, Thomas Durcan, Miratul Muqit, Wolfdieter Springer
Structure-based design of small-molecule activators of Parkin.
2016-2020
Principal Investigator: Jean-François Trempe
Collaborators: David Drewry, William Zuercher, Aled Edwards (SGC)
Crystal Structure of PINK1.
2016-2017
Principal Investigator: Jean-François Trempe
Collaborators: Gergely Lukacs
HEALTHY BRAIN FOR HEALTHY LIVES
Measuring protein turnover in organoid and animal models of Parkinson’s disease.
2018-2020
Principal Investigator: Jean-François Trempe
Collaborators: Thomas Durcan, Edward Fon
CANADIAN FUND FOR INNOVATION (CFI)
Leaders Opportunity Fund (LOF) linked to Canada Research Chair. Structural Pharmacology of Parkinson's disease.
2014-2019
Principal Investigator: Jean-François Trempe
PARKINSON CANADA
Small molecule stabilizers as PINK1 agonists: a proof-of-concept study.
2017-2018
Principal Investigator: Jean-François Trempe
New Investigator Award. Crystal structure of PINK1.
2014-2016
Principal Investigator: Jean-François Trempe