Dept of Pharmacology & Therapeutics
Jean-Francois Trempe obtained his doctorate degree from the University of Oxford in 2007. After postdoctoral training at McGill and the Montreal Neurological Institute, he obtained a Faculty position at McGill in 2013. His goal is to elucidate the function of proteins implicated in Parkinson’s disease (PD) through 3D structure determination and proteomics studies, as well as design small molecules to modulate their activities. In collaboration with the Michael J. Fox Foundation and the SGC, his lab aims to design and characterize small-molecules activators for Parkin and PINK1. He holds a Tier 2 Canada Research Chair in Structural Pharmacology and has received the New Investigator Award from Parkinson Canada in 2014. He has published a total of 52 articles during his career (H-index 24, 2880 citations), mostly on the topics of ubiquitin and neurodegenerative diseases. His most important contribution to date is the structure determination of Parkin, which revealed the mechanism of action of this important PD target. The work was a collaboration with Véronique Sauvé in the lab of Kalle Gehring (Trempe, Sauvé et al. Science 2013).
Ms Nathalie Croteau is a laboratory technician who’s been working at McGill for more than 30 years. She obtained a BSc degree in Biochemistry from McGill in 1987, after which she started to work as a technician at McGill, in the labs of Drs Andrew Bateman and Samuel Solomon (1987-1994). In 1994, she joined the lab of Dr Alice Vrielink (McGill Biochemistry). After the departure of Dr Vrielink from McGill in 2001, Ms Croteau joined the lab of Prof James Coulton in the department of Microbiology & Immunology, where she worked until his retirement. She joined Dr Trempe in November 2013, and has since been the cornerstone of the laboratory.
Simon obtained a PhD under the direction of Jacqueline Cherfils, at the CNRS Laboratoire de Biologie et Pharmacologie Appliquée, ENS Paris-Saclay, France. His project consisted of elucidating the structure and mechanism of action of FIC proteins. He joined the Trempe lab in November 2018. His project, funded by the Michael J Fox Foundation, is to design and optimize small-molecule activators of Parkin, using NMR and X-ray crystallography.
Shafqat obtained a undergraduate degree in Biology from the Lahore University of Management Sciences (Pakistan) in 2013. He joined our lab in 2014, completed a MSc thesis in 2015, and then started a PhD. His objective is to determine the structure and mechanism of action of the ubiquitin kinase PINK1. He holds a doctoral award from Parkinson Canada and sits on the executive student council of the Centre de Recherche en Biologie Structurale (CRBS).
Andrew graduated with a BSc (Major in Pharmacology, Minor in Chemistry) in 2016. He started working in the lab in his U3 year as part of the PHAR599 course. He then joined the lab as a MSc student, and transferred to PhD. He works on the mitochondrial processing peptidase, a protein regulating the import of nuclear-encoded mitochondrial proteins and involved in cerebellar ataxia. He holds a CIHR doctoral award.
Anthony obtained a BSc in Neuroscience from Dalhousie University, and then joined our lab in 2017. He studies protein turnover in midbrain-like organoids using stable isotope labeling and mass spectrometry. He was previously supported by a CGS CIHR award. This project is supported by a Discovery grant from the CFREF Healthy Brains for Healthy Lives initiative.
Sophie graduated with a BSc in Pharmacology at McGill, before starting her MSc in 2018. Her goal is to elucidate the basis of Parkin substrate specificity using proximity-ligation assays and in vitro ubiquitination assays. She holds a studentship from the Centre de Recherche en Biologie Structurale.
Jerry is pursuing a Honours degree in Pharmacology at McGill. He started a research project as part of the PHAR598 course in September 2019.
Tara is doing a Major in Pharmacology at McGill (U3). She started as a summer student in May 2019, and is currently carrying a project for PHAR599.