PUBLICATIONS

2024

Sauvé V, Stefan E, Croteau N, Goiran T, Fakih R, Bansal N, Hadzipasic A, Fang J, Fon EA, Hirst WD, Silvian LF#, Trempe JF, Gehring K# (2024) Activation of Parkin by a molecular glue. Nature Communications, 15: 7707. PMID 39300082

Cummer R, Grosjean F, Bolteau R, Vasegh SE, Veyron S, Keogh L, Trempe JF, Castagner B# (2024) Structure-Activity Relationship of Inositol Thiophosphate Analogs as Allosteric Activators of Clostridioides difficile Toxin B. Journal of Medicinal Chemistry, doi: 10.1021/acs.jmedchem.4c01408. PMID 39254660

Saran A, Kim HM, Manning I, Hancock MA, Schmitz C, Madej M, Potempa J, Sola M, Trempe JF, Zhu Y, Davey ME, Zeytuni N# (2024) Unveiling the molecular mechanisms of the type IX secretion system's response regulator: Structural and functional insights. PNAS Nexus, 3(8):pgae316. PMID 39139265

Penalva YCM, Paschkowsky S, Recinto SJ, Duchesne A, Hammond T, Spiegler P, Jansen G, Levet C, Charron F, Freeman M, McKinney RA, Trempe JF, Munter LM# (2024) Eta-secretase-like processing of the amyloid precursor protein (APP) by the rhomboid protease RHBDL4. Journal of Biological Chemistry, 300(8):107541. PMID 38992438

Rasool S*, Shomali T*, Truong L, Croteau N, Veyron S, Bustillos BA, Springer W, Fiesel FC, Trempe JF# (2024) Identification and structural characterization of small molecule inhibitors of PINK1. Scientific Reports, 14(1):7739. PMID 38565869

Eldeeb MA*, Bayne AN*, Fallahi A, Goiran T, MacDougall EJ, Soumbasis A, Zorca CE, Tabah JJ, Thomas RA, Karpilovsky N, Mathur M, Durcan TM, Trempe JF#, Fon EA# (2024) TOM20 gates PINK1 activity and mediates its tethering of the TOM and TIM23 translocases upon mitochondrial stress. Proceedings of the National Academy of Sciences U.S.A. 121:e2313540121. PMID 38416681

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2023

Yu E, Larivière R, Thomas RA, Liu L, Senkevich K, Rahayel S, Trempe JF, Fon EA, Gan-Or Z# (2023) Machine learning nominates the inositol pathway and novel genes in Parkinson's disease. Brain, Oct 6:awad345. PMID 37804111

Senkevich K, Beletskaia M, Dworkind A, Yu E, Ahmad J, Ruskey JA, Asayesh F, Spiegelman D, Fahn S, Waters C, Monchi O, Dauvilliers Y, Dupré N, Greenbaum L, Hassin-Baer S, Nagornov I, Tyurin A, Miliukhina I, Timofeeva A, Emelyanov A, Trempe JF, Zakharova E, Alcalay RN, Pchelina S, Gan-Or Z# (2023) Association of Rare Variants in ARSA with Parkinson's Disease. Movement Disorders, doi:10.1002/mds.29521. PMID 37381728

Trempe JF#, Gehring K# (2023) Structural mechanisms of mitochondrial quality control mediated by PINK1 and parkin. Journal of Molecular Biology, 12:168090. PMID 37054910

Bayne AN*, Dong J*, Amiri S, Farhan SMK#, Trempe JF# (2023) MTSviewer: a database to visualize mitochondrial targeting sequences, cleavage sites, and mutations on protein structures. PLoS One, 18: e0284541. PMID 37093842

Stevens MU*, Croteau N*, Eldeeb MA*, Antico O, Zeng ZW, Toth R, Durcan TM, Springer W, Fon EA#, Muqit MMK#, Trempe JF# (2023) Structure-based design and characterization of Parkin activating mutations. Life Science Alliance, e202201419. PMID 36941054  

Khan SM*, Martin RD*, Bayne AN, Pétrin D, Bourque K, Jones-Tabah J, Bouazza C, Blaney J, Lau J, Martins-Cannavino K, Gora S, Zhang A, MacKinnon S, Trieu P, Clarke PBS, Trempe JF, Tanny JC#, Hébert TE# (2023) Gβγ subunits colocalize with RNA polymerase II and regulate transcription in cardiac fibroblasts. Journal of Biological Chemistry, 299:103064. PMID 36841480

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2022

Senkevich K, Zorca CE, Dworkind A, Rudakou U, Somerville E, Yu E, Ermolaev A, Nikanorova D, Ahmad J, Ruskey JA, Asayesh F, Spiegelman D, Fahn S, Waters C, Monchi O, Dauvilliers Y, Dupré N, Greenbaum L, Hassin-Baer S, Grenn FP, Chiang MSR, Sardi SP, Vanderperre B, Blauwendraat C, Trempe JF, Fon EA, Durcan TM, Alcalay RN, Gan-Or Z# (2022) GALC variants affect galactosyl-ceramidase enzymatic activity and risk of Parkinson's disease. Brain, 146:1859-1872. PMID 36370000

Varghaei P, Estiar MA, Ashtiani S, Veyron S, Mufti K, Leveille E, Yu E, Spiegelman D, Rioux MF, Yoon G, Tarnopolsky M, Boycott KM, Dupre N, Suchowersky O, Trempe JF, Rouleau GA, Gan-Or Z# (2022) Genetic, structural and clinical analysis of spastic paraplegia 4. Parkinsonism Related Disorders, 98:62-69. PMID 35487127

Maruszczak KK, Jung M, Rasool S, Trempe JF, Rapaport D# (2022) The role of the individual TOM subunits in the association of PINK1 with depolarized mitochondria. Journal of Molecular Medicine, 100:747-762. PMID 35391620

Dong J*, Duchesne A*, Bayne AN*, Mohamed NV, Yi W, Mathur M, Chen CXQ, You Z, Abdian N, Taylor L, Fon EA, Durcan TM, Trempe JF# (2022) An approach to measuring protein turnover in human induced pluripotent stem cell organoids by mass spectrometry. Methods, 203:17-27. PMID 35331912

Vranas M*, Lu Y*, Rasool S, Croteau N, Krett JD, Sauvé V, Gehring K, Fon EA, Durcan TM, Trempe JF# (2022) Selective localization of Mfn2 near PINK1 enable its preferential ubiquitination by Parkin on mitochondria. Open Biology, 12:210255. PMID 35042405

Rasool S, Veyron S, Soya N, Eldeeb M, Lukacs G, Fon EA, Trempe JF# (2022). Mechanism of PINK1 activation by autophosphorylation and insights into assembly on the TOM complex. Molecular Cell, 82:1-16. PMID 34875213

2021

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Shi F, Aloufi N, Traboulsi H, Trempe JF, Eidelman DH, Baglole CJ# (2021) Endogenous regulation of the Akt pathway by the aryl hydrocarbon receptor (AhR) in lung fibroblasts. Scientific Reports, 11(1):23189. PMID 34848742

 

Sosero YL, Yu E, Estiar MA, Krohn L, Mufti K, Rudakou U, Ruskey JA, Asayesh F, Laurent SB, Spiegelman D, Trempe JF, Quinnell TG, Oscroft N, Arnulf I, Montplaisir JY, Gagnon JF, Desautels A, Dauvilliers Y, Gigli GL, Valente M, Janes F, Bernardini A, Sonka K, Kemlink D, Oertel W, Janzen A, Plazzi G, Antelmi E, Biscarini F, Figorilli M, Puligheddu M, Mollenhauer B, Trenkwalder C, Sixel-Döring F, Cochen De Cock V, Monaca CC, Heidbreder A, Ferini-Strambi L, Dijkstra F, Viaene M, Abril B, Boeve BF, Postuma RB, Rouleau GA, Ibrahim A, Stefani A, Högl B, Hu MTM, Gan-Or Z# (2021) Rare PSAP Variants and Possible Interaction with GBA in REM Sleep Behavior Disorder. J Parkinson Disease. PMID 34690151

 

Torrealba-Acosta G#, Yu E, Lobo-Prada T, Ruíz-Martínez J, Gorostidi-Pagola A, Gan-Or Z, Carazo-Céspedes K, Trempe JF, Mata IF, Fornaguera-Trías J (2021) Clinical and Genetic Analysis of Costa Rican Patients With Parkinson's Disease. Frontiers Neurology,12: 656342. PMID 34421783

 

Varghaei P, Yoon G, Estiar MA, Veyron S, Leveille E, Dupré N, Trempe JF, Rouleau GA, Gan-Or Z# (2021) GCH1 mutations in hereditary spastic paraplegia. Clinical Genetics, 100:51-58. PMID 33713342

 

Estiar MA, Yu E, Haj Salem I, Ross JP, Mufti K, Akçimen F, Leveille E, Spiegelman D, Ruskey JA, Asayesh F, Dagher A, Yoon G, Tarnopolsky M, Boycott KM, Dupre N, Dion PA, Suchowersky O, Trempe JF, Rouleau GA, Gan-Or Z# (2021) Evidence for Non-Mendelian Inheritance in Spastic Paraplegia 7. Movement Disorders, 36:1664-1675. PMID 33598982

 

Khan N*, Pelletier D*, McAlear TS, Croteau N, Veyron S, Bayne AN, Black C, Ichikawa M, Khalifa AAZ, Chaaban S, Kurinov I, Brouhard G, Bechstedt S, Bui KH, Trempe J-F# (2021) Crystal structure of human PACRG in complex with MEIG1 reveals roles in axoneme formation and tubulin binding. Structure, 29:572-586. PMID 33529594

 

Mufti K, Yu E, Rudakou U, Krohn L, Ruskey JA, Asayesh F, Laurent SB, Spiegelman D, Arnulf I, Hu MTM, Montplaisir JY, Gagnon JF, Desautels A, Dauvilliers Y, Gigli GL, Valente M, Janes F, Bernardini A, Högl B, Stefani A, Holzknecht E, Sonka K, Kemlink D, Oertel W, Janzen A, Plazzi G, Antelmi E, Figorilli M, Puligheddu M, Mollenhauer B, Trenkwalder C, Sixel-Döring F, Cochen De Cock V, Monaca CC, Heidbreder A, Ferini-Strambi L, Dijkstra F, Viaene M, Abril B, Boeve BF, Trempe J-F, Rouleau GA, Postuma RB, Gan-Or Z# (2021). Novel Associations of BST1 and LAMP3 With REM Sleep Behavior Disorder. Neurology. e1402-e1412. PMID 33397775​

 

Robert RF, Bayne AN, Goiran T, Lévesque D, Boisvert F-M, Trempe J-F, Fon EA# (2021) Proteomic profiling of mitochondrial-derived vesicles in brain reveals enrichment of respiratory complex sub-assemblies and small TIM chaperones. Journal of Proteome Research, 20: 506-517. PMID 33242952

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2020

 

Eldeeb MA, Bayne AN, Trempe J-F, Fon EA# (2020) Fine-tuning TOM-mitochondrial import via ubiquitin. Trends in Cell Biology, 30: 425-427. PMID 32345464

 

Khalifa A, Ichikawa M, Dai D, Black C, Peri K, McAlear TS, Kubo S, Veyron S, Yang SK, Vargas J, Trempe J-F, Bechstedt S, Bui KH# (2020) The inner junction complex of the cilia is an interaction hub that involves tubulin post-translational modifications. Elife ,e52760, PMID 31951202

 

Semmler S, Gagné M, Garg P, Pickles SR, Baudouin C, Hamon-Keromen E, Destroismaisons L, Khalfallah Y, Chaineau M, Caron E, Bayne AN, Trempe J-F, Cashman NR, Star AT, Haqqani AS, Durcan TM, Meiering EM, Robertson J, Grandvaux N, Plotkin SS, McBride HM,  Vande Velde C# (2020) The E3 ubiquitin ligase TRAF6 is a novel interacting protein of amyotrophic lateral sclerosis-linked misfolded SOD1. Journal of Biological Chemistry, 295: 3808-3825, PMID 32029478

 

Estiar MA, Léveillé E, Spiegelman D, Dupré N, Trempe J-F, Rouleau GA, Gan-Or Z# (2020) Clinical and genetic analysis of ATP13A2 in hereditary spastic paraplegia expands the phenotype. Molecular Genetics Genomic Medecine, pii: e1052. PMID 31944623

 

Krohn L, Öztürk TN, Vanderperre B, Ouled Amar Bencheikh B, Ruskey JA, Laurent SB, Spiegelman D, Postuma RB, Arnulf I, Hu MTM, Dauvilliers Y, Högl B, Stefani A, Monaca CC, Plazzi G, Antelmi E, Ferini-Strambi L, Heidbreder A, Rudakou U, Cochen De Cock V, Young P, Wolf P, Oliva P, Zhang XK, Greenbaum L, Liong C, Gagnon JF, Desautels A, Hassin-Baer S, Montplaisir JY, Dupré N, Rouleau GA, Fon EA, Trempe JF, Lamoureux G, Alcalay RN, Gan-Or Z# (2020) Genetic, Structural, and Functional Evidence Link TMEM175 to Synucleinopathies. Annals of Neurology, 87: 139-153. PMID 31658403

 

2019

 

Bayne AN, Trempe J-F# (2019) Mechanisms of PINK1, ubiquitin and Parkin interactions in mitochondrial quality control and beyond. Cellular and Molecular Life Sciences, 76: 4589-4611. PMID 31254044

 

Léveillé E, Estiar MA, Krohn L, Spiegelman D, Dionne-Laporte A, Tarnopolsky M, Boycott KM, Yoon G, Suchowersky O, Dupré N, Trempe J-F, Rouleau GA, Gan-Or Z# (2019) SPTAN1 mutations cause autosomal recessive hereditary spastic paraplegia. Journal of Human Genetics, 64: 1145-1151. PMID 31515523

 

Fava VM, Xu YZ, Lettre G, Thuc NV, Orlova M, Thai VH, Croteau N, Eldeeb MA, MacDougall EJ, Cambri G, Tao S, Lahiri R, Adams L, Fon EA, Trempe J-F, Cobat A, Alcaïs A, Abel L, Schurr E# (2019) Pleiotropic effects for Parkin and LRRK2 in leprosy type-1 reactions and Parkinson’s Disease. Proceedings of the National Academy of Sciences U.S.A. 116: 15616-15624. PMID 31308240

 

Svoboda M, Konvalinka J, Trempe J-F, Šašková KG# (2019). The yeast proteases Ddi1 and Wss1 are both involved in the DNA replication stress response. DNA Repair (Amst), 80: 40-51. PMID 31276951

 

Yi W, MacDougall EJ, Tang MY, Krahn AI, Gan-Or Z, Trempe J-F, Fon EA# (2019) The Landscape of Parkin Variants Reveals Pathogenic Mechanisms and Therapeutic Targets in Parkinson's Disease. Human Molecular Genetics, pii: ddz080. PMID 30994895

 

Alcalay RN, Mallett V, Vanderperre B, Tavassoly O, Dauvilliers Y, Leblond CS, Ambalavanan A, Laurent SB, Spiegelman D, Dionne-Laporte A, Liong C, Levy OA, Fahn S, Waters C, Kuo SH, Chung WK, Ford B, Marder KS, Kang UJ, Hassin-Baer S, Greenbaum L, Trempe J-F, Wolf P, Oliva P, Zhang XK, Clark LN, Langlois M, Dion PA, Fon EA, Dupré N, Rouleau GA, Gan-Or Z (2019) SMPD1 mutations activity and a-synuclein accumulation in Parkinson's disease. Movement Disorders, 34: 526-535. PMID 30788890

 

Laughlin TG, Bayne AN, Trempe J-F, Savage DF, Davies KM#. (2019) Structure of NDH the complex I-like molecule of oxygenic photosynthesis. Nature, 566: 411-414. PMID 30742075

 

2018

 

Trempe, J-F#, Gehring K# (2018). Small-angle X-ray scattering for the study of proteins in the ubiquitin pathway. In: Mayor & Kleiger (eds) The Ubiquitin Proteasome System, Methods in Molecular Biology. 1844: 197-208. PMID 30242711

 

Rasool S, Trempe J-F# (2018). New insights into the structure of PINK1 and the mechanism of ubiquitin phosphorylation. Critical Reviews in Biochemistry and Molecular Biology. 21: 1-20. PMID 30238821

 

Sauvé V*, Sung G*, Soya N, Kozlov G, Blaimschein N, Miotto LS, Trempe J-F#, Lukacs GL, Gehring K# (2018). Mechanism of parkin activation by phosphorylation. Nature Structural and Molecular Biology, 25: 623-630. PMID 29967542

 

Ménade M*, Kozlov G*, Trempe J-F*, Pande H, Shenker S, Wickremasinghe S, Dicaire M-J, Li X, Brais B, McPherson PS, Gehring K# (2018). Structures of Ubl and Hsp90-like domains of sacsin provide insight into pathological mutations. Journal of Biological Chemistry, 293: 12832-42. PMID 29945973

 

Ruskey JA, Zhou S, Santiago R, Franche LA, Alam A, Roncière L, Spiegelman D, Fon EA, Trempe J-F, Kalia LV, Postuma RB, Dupre N, Rivard GE, Assouline S, Amato D, Gan-Or Z# (2018). The GBA p.Trp378Gly mutation is a probable French-Canadian founder mutation causing Gaucher disease and synucleinopathies. Clinical Genetics, 94:339-345. PMID 29920646

 

McLelland G-L, Yi W, Dorval G, Chen CX, Lauinger ND, Valimehr S, Rakovic A, Rouiller I, Durcan TM, Trempe J-F, Fon EA# (2018). Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy. eLife, 7:e32866. PMID 29676259

 

Rasool S, Soya N*, Truong L*, Croteau N, Lukacs G, Trempe J-F# (2018). PINK1 autophosphorylation is required for ubiquitin recognition. EMBO Reports, 19: e44981. doi: 10.15252/embr.201744981. PMID 29475881

 

2017

 

Tang MY*, Vranas M*, Krahn AI, Pundlik S, Trempe J-F#, Fon EA# (2017) Structure-guided mutagenesis reveals a hierarchical mechanism of Parkin activation. Nature Communications, 8:14697. PMID 28276439

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2016

 

Trempe J-F#, Šašková KG, Sivá M, Ratcliffe CD, Veverka V, Hoegl A, Ménade M, Feng X, Shenker S, Svoboda M, Kožíšek M, Konvalinka J, Gehring K (2016). Structural studies of the yeast DNA damage-inducible protein Ddi1 reveal domain architecture of this eukaryotic protein family. Scientific Reports, 6:33671. PMID 27646017

 

Sivá M, Svoboda M, Veverka V, Trempe J-F, Hofmann K, Kožíšek M, Hexnerová R, Sedlák F, Belza J, Šácha P, Hubálek M, Starková J, Flaisigová I, Konvalinka J, Šašková KG# (2016). Human DNA-Damage-Inducible
2 Protein is structurally and functionally distinct from its yeast ortholog. Scientific Reports, 6:30443. PMID 27461074

 

2015

 

Sauvé V*, Lilov A*, Seirafi M*, Vranas MM, Rasool S, Kozlov G, Sprules T, Wang J, Trempe J-F#, Gehring K#. (2015) A Ubl/ubiquitin switch in the activation of Parkin. EMBO Journal, e201592237. PMID 26254305

 

Aguileta MA, Korac J, Durcan TM, Trempe J-F, Haber M, Gehring K, Elsasser S, Waidmann O, Fon EA, Husnjak K. (2015) The E3 ubiquitin ligase parkin is recruited to the 26 S proteasome via the proteasomal ubiquitin receptor Rpn13. Journal of Biological Chemistry, 290: 7492-505. PMID 25666615
 

2014

 

Koyano F, Okatsu K, Kosako H, Tamura Y, Go E, Kimura M, Kimura Y, Tsuchiya H, Yoshihara H, Hirokawa T, Endo T, Fon EA, Trempe J-F, Saeki Y, Tanaka K, Matsuda N. (2014) Ubiquitin is phosphorylated by PINK1 to activate parkin. Nature, 510: 162-6. PMID 24784582